Nanyang Polytechnic was established on 1 April 1992, and enrolled its first batch of students for its School of Health Sciences and School of Business Management in July 1992. The School of Engineering and the School of Information Technology was opened in July 1993.

Nanyang Polytechnic is a polytechnic located in the precinct of Yio Chu Kang in the town of Ang Mo Kio, Singapore. As an industry-oriented alternative to a broader based junior college education, polytechnic graduates in Singapore are sought after for work or many continue to complete university degrees.